Pipeline

Product pipeline

We have six projects in clinical development and five projects in late discovery or pre-clinical development. We target some of the largest epithelial cancer indications, such as colorectal and lung cancers.

Our clinical pipeline comprises  two RTK oncology projects, EGFR (Sym004) and MET (Sym015), and five immune-oncology projects targeting PD1 (Sym021), LAG3 (Sym022), TIM3 (Sym023) and CD73 (Sym024). We are also advancing several discovery or pre-clinical projects, including our FLT3 (Sym027), AXL (Sym028) and CD40 (Sym029) projects. Status and future plans are outlined in this pipeline section.

Proprietary assets

Oncology
Discovery
Pre-clinical
Phase 1
Phase 2
Metastatic Colorectal Cancer
Lung cancer
Solid tumors
Solid tumors
Solid tumors
Cancer
Cancer
Cancer
Cancer
Cancer
Cancer

Our focus

We target some of the largest epithelial cancer indications, such as colorectal and lung cancers.

The partnered clinical-stage projects are an immuno-oncology program of six targets being developed in collaboration with Servier, three of which are in Phase 1 development, and a project directed to Staphylococcus aureus bacteremia, which is in Phase 1 development by Genentech.

In addition to our clinical trials, we maintain extensive proprietary and partnered discovery and preclinical activities to continue to realize the potential of our technology platform.

What are antibodies?

Antibodies are Y-shaped proteins produced by specialized cells of the body’s immune system. Antibodies can identify and bind disease-specific antigens found on bacteria, viruses, and cancer cells. Once attached to the antigen, antibodies can recruit other parts of the immune system to help neutralize the cells containing the antigen. The place on the antigen where the antibody binds is called an epitope. Researchers can design antibodies to target a certain antigen. Antibodies can be made in large amounts known as monoclonal antibodies (mAbs). Monoclonal antibodies are a well-established drug class today used to treat many diseases, including cancer.

Immuno-oncology
Immuno-oncology is the study and development of immuno-therapies that use certain parts of a person’s immune system to fight cancer. Immunotherapies target cancer cells that have found ways to use checkpoint molecules to avoid being attacked by the immune system, allowing the cancer to grow.
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Receptor tyrosine kinases
RTKs (such as EGFR and MET) are a large family of cell-surface transmembrane receptors. RTKs play a crucial role in regulating a range of cellular functions, including growth, proliferation, differentiation, and survival. Their activity is normally tightly controlled and regulated by the body. Deregulated RTK activation and amplification is frequently seen in human cancers.
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Read publications for an in-depth view on our science