Principal Scientist, In Vivo Pharmacology

Back to Careers

As Principal Scientist in the In Vivo Pharmacology department at Symphogen you will lead and participate in activities related to generating in vivo proof-of-concept for new targets and for lead antibody candidates across Symphogens project portfolio within oncology, immune oncology, and immune-inflammation. You will be in charge of developing in vivo and ex vivo models to analyze efficacy of antibodies with various mode-of-action based on epitope and isotype. In addition, you will be involved in exploring various antibody formats to further develop and enhance antibody-based therapeutics. These studies include, but are not limited to, investigation of FcR interactions and secondary effector functions, multi-specific antibodies and bi-specific antibodies.

With direct report Team Manager of In Vivo Pharmacology.

Other tasks include:

  • Planning and documentation of in vivo efficacy data in regulatory submissions in the early applications in collaboration with other specialists
  • Participate and setup cross functional meetings at a regular basis providing input to biology, mode-of-action, indication selection, and potential biomarkers
  • Provide scientific leadership and direction in discussions, development, and evaluation of all new developments within field of oncology and immune-oncology and development of therapeutic antibodies
  • Serves as a mentor in tutoring and educating R&D staff as well as collaborating with our research and nonclinical departments

You have a PhD in cancer biology, immunology, pharmacology, or related discipline combined with several years of post-doctoral antibody related in vivo experience and preferable 2-3 years of experience with in vivo oncology/immunology from the industry.

Further, your qualifications include:

  • Extensive experience with in vivo models evaluating therapeutic antibodies including the impact of various Fc formats
  • In-depth knowledge of in vivo models within immune oncology e.g. immune humanized models, GEMM, and human and murine tumor models
  • Hands-on experience with techniques for functional characterization of cancer and immune cells, in particular flow cytometry and gene expression analysis
  • Experience with rodent anatomy, physiology, and pathology
  • Preferably robust knowledge of R&D
  • Strong communication and language skills, written and verbal in English

You are a person with a proactive and dynamic approach who are higly self-driven and seeking to achieve all goals. You are a team player at heart and you provide god energy within the group as well as between departments. You are an innovative scientist able to advance on challenging projects and is acting agile and flexible when changes occur.

Symphogen offers an exciting and highly complex opportunity in an innovative, flexible, focused and committed biotech environment. Moreover, they offer strong cross-functional teamwork and room for individual performance. You will have passionate colleagues with lots of open dialogues, agility, empowerment, and fun. The location has optimized labs and equipment for antibody discovery and development including a state-of-the-art animal facility with high standards of animal well fare.

Travelling: 10-15 days a year.

Domicile: Symphogen’s office in Ballerup.

Unique Human Capital is handling the recruitment and for more details about the job, please contact CEO Jørn Duhn, Unique Human Capital on M: +45 21 75 19 25 or Senior Research Consultant, Elisabeth Haun, Unique Human Capital on M: +45 28 90 33 88. All applications must be submitted in English and are treated confidentially.

Apply directly via this link: https://uhc.dk/ledige-stillinger/principal-scientist-in-vivo-pharmacology/

 

Company

Symphogen is a subsidiary of Servier and antibody center of excellence primarily focused on oncology and immune oncology. We have a highly efficient antibody discovery and research platform supported by comprehensive early development capabilities.

Our antibody platform delivers antibodies with unique functionalities providing best or first in class potential as combination or mono therapy. Our approach and capabilities are well suited for combination therapies at the core of future cancer treatment.

Symphogen is located in Ballerup in the greater Copenhagen area. The company currently employs approximately 100 people

Open positions

August 31, 2021
Ballerup

Analytical Scientist for Analytical Development

The position as analytical scientist offers a unique possibility to take part in the development of Symphogen antibody products. The position is in the Analytical Support team in the Analytical Development department and the team currently employs 4 scientists and 7 technicians. The position is a 2-year temporary position. Analytical Development contribute to advancing our targets through lead selection, clinical development, and commercialization. As Analytical Scientist, you will be a key player in an interdisciplinary project team.
Read more
July 12, 2021
Ballerup

Analytical Coordinator

A Unique opportunity to take part in the development of antibody products. As Analytical Coordinator at Symphogen you will work with advancing antibody targets through lead selection and clinical development.
Read more
July 12, 2021
Ballerup

Senior Downstream Scientist in Drug Substance Development

The position as Senior Downstream Scientist in Drug Substance Development at Symphogen is a unique possibility to play an important role in the CMC development of their antibody products. The position requires expertise within late-stage development of therapeutic proteins downstream processes.
Read more
June 2, 2021
Ballerup

(Senior) Scientist for Drug Product Development

The CMC function at Symphogen is integrated with the Servier CMC group in a strong international collaboration. Together we support projects in all phases of development from early discovery to process validation and beyond. To help us reach our mission we are looking for experienced and motivated candidates to the following position as a (Senior) Scientist for Drug Product Development. The position offers a unique possibility to take part in the development of Symphogen antibody products, and is anchored in the drug product development department within in CMC Biologics.
Read more
Our vision and culture