The analytical development department comprises 25 scientists and technicians whereof 8 are focused on characterization. The department is specializing in protein analysis to support characterization, method development, troubleshooting, process development, validation, stability studies, and more.
The vacant position is in the mass spectrometry team where we are seeking a candidate with experience within both peptide and intact MS characterization of biologics e.g. monoclonal and bispecific antibodies as well as antibody-drug conjugates (ADCs).
The MS laboratory is equipped with a state-of-the-art Orbitrap mass spectrometry platform where most chromatographic methods are hyphenated to the mass spectrometers (SEC-MS, CIEX-MS, RPC-MS and CE-MS). Data processing is performed in Chromeleon or Protein Metrics software (Byosphere Enterprise). As a (senior) scientist you are responsible for the characterization strategy, development of new methods, implementation of new instruments, troubleshooting, and support to both research and CMC projects. The laboratory work is performed by our experienced technicians, while data processing is either performed by the scientist or technician, depending on the scope. From time to time, some work in the lab can be expected for the scientist, mainly related to development tasks. In addition, the role includes coordination between multiple stakeholders in different project groups.
The Analytical characterization team is also responsible for biophysical characterization of our drug candidates, why understanding of biophysical characterization of biologics is an advantage. Relevant experience include the following equipment; dynamic light scattering (DLS), subvisible particle measurements (MFI, Flowcam) and nano-differential scanning fluorimetry (Prometheus).
As a person you are highly motivated, proactive, and enjoy new challenges while working in a structured and organized environment. You will have the opportunity to work alongside a team of experienced scientists, technicians and industry experts, fostering a collaborative atmosphere that encourages knowledge-sharing and innovation while supporting the research and CMC projects and each other.
Required Qualifications
- Relevant education such as Ph.D., cand. scient, cand.polyt., cand. pharm. or equivalent
- Experience with mass spectrometric characterization of biopharmaceuticals preferably antibodies by LC-MS/(MS) (peptide mapping, intact mass)
- Experience with relevant equipment e.g. Orbitrap mass spectrometry and (U)HPLC in general
- Advanced knowledge about physical and chemical properties of proteins
- Strong communication and language skills, written and verbal (English)
- Self-driven, highly motivated team player with commitment, initiative and humor
Preferred Qualification
- Experience with developability assessment of antibodies
- Experience with CMC development of biopharmaceuticals preferably antibodies and ADCs
- Knowledge of biophysical characterization of biopharmaceuticals and relevant equipment
- Knowledge of general analytical techniques e.g. HPLC, CE-SDS, iCIEF, concentration determination
We offer
- A challenging and versatile job in an innovative, focused and committed biotech environment
- Competitive salary based on qualifications, and flexible working hours
- Strong cross functional teamwork, room for individual performance and development, and passionate, inspiring, and fun colleagues
Working in Symphogen
Being part of Symphogen, you will have a challenging job in a creative, goal-oriented, and value-based environment with a meaningful mission: to advance superior monoclonal antibody therapeutics to improve the lives of patients. You will be a part of a highly engaged and inspiring organization with a focus on diversity, teamwork, commitment – and on you as a person. You will be offered good development opportunities and a relevant benefit package.
For further information
For more information you are welcome to contact Pernille Foged Jensen, Team Manager, Analytical Characterization at +45 88382430 (pfje@symphogen.com) or HR-Manager, Pia Holm Olesen at +45 45265050. Please also see www.symphogen.com for information about our company.
If you are interested in the position, please mark your application and CV “Characterization scientist” and mail it to: job@symphogen.com no later than January 20, 2025. Potential candidates will be invited for interview as they apply, and we reserve the right to terminate before the posting expires.
We look forward to hearing from you!
Company
Symphogen is a subsidiary of Servier and antibody center of excellence primarily focused on oncology and immune oncology. We have a highly efficient antibody discovery and research platform supported by comprehensive early development capabilities.
Our antibody platform delivers antibodies with unique functionalities providing best or first in class potential as combination or mono therapy. Our approach and capabilities are well suited for combination therapies at the core of future cancer treatment.
Symphogen is located in Ballerup in the greater Copenhagen area. The company currently employs approximately 150 people