Symphogen A/S was recently acquired by Servierand has entered an exciting expansion phase as Servier’s Antibody Center of Excellence. As Principal Scientist at Symphogen you will, together with the Antibody Technology team, be responsible for all recombinant single B cell workflows and antibody engineering needed to support the discovery projects.
The main objective for you will be to innovate molecular biology processes for recombinant antibody repertoire cloning and engineering using the human antibody transgenic animals and high throughput single B cell cloning workflows. This is a senior level position that requires solid scientific expertise, attention to detail and the ability to work in a team-oriented culture where knowledge sharing and idea generation with peers is key for advancing next generation antibody therapeutics.
Your main tasks and responsibilities will be:
- Deliver scientific impact within design and execution of existing and novel workflows for antibody discovery
- Perform antibody engineering approaches like e.g. IgG Fc/isotype optimization or other optimizations
- Communicate results in clear and effective manner to senior management
- Implement novel antibody formats or workflows for multi-specific antibodies
- Coordinate activities within focus group
- Help junior staff build key skills and further develop their careers
- Supervise one lab technician and one student
Your qualifications within antibody related experience makes you a role model and a scientific trendsetter, and your excellent oral and written communication skills are exemplified in public presentations, publications and patent applications. You are excellent at working effectively and goal oriented in a multi-disciplinary setting with many different priorities.
You have a Ph.D. degree in immunology, molecular biochemistry, or other related biological science combined with several years of post-doctoral antibody related experience and a minimum of 5 years industry experience in antibody related research. You have solid molecular biology experience with antibody repertoire cloning approaches and particular experience with primer and vector design is key for this position.
Further experience with one of the following areas will be an advantage:
- Antibody humanization
- Next generation sequencing (NGS) analysis
- Optimizing antibody genes for good drug properties and low immunogenicity
- Synthetic antibody libraries (phage or yeast display)
- CLC Genomics Workbench, Genedata Biologics or similar software
Symphogen offers a unique senior position at the Antibody Center of Excellence with cutting edge antibody technologies to help find the best leads, bring them into clinic and finally improve the lives of cancer patients worldwide. The location has optimized labs and equipment for antibody discovery and development including a state of the art animal facility. You will have passionate colleagues with lots of open dialogues, agility, empowerment and fun.
Domicile: Ballerup, Copenhagen.
For more details about the job or the company, please contact Unique Human Capital, CEO Jørn Duhn on M: +45 21 75 19 25 or Senior Research Consultant Anne Thomsen on M: +45 31 40 01 11. All applications must be in English and are treated confidentially.
Please apply through this link: https://uhc.dk/ledige-stillinger/principal-scientist/
Symphogen A/S was founded in 2000 and was in June 2020 acquired by Servier, an international pharmaceutical company governed by a non-profit foundation. Servier’s headquarter is located in Paris, France and has a strong international presence in 149 countries and a total revenue of 4.6 billion euros and approximately 22,000 employees worldwide.
Entirely independent, the Group invests on average 25% of its total revenue (excluding generics) every year in research and development and uses all its profits for its development. Corporate growth is driven by Servier’s constant search for innovation in five areas of excellence: cardiovascular, immune-inflammatory, and neurodegenerative diseases, cancer and diabetes, as well as by its activities in high-quality generic drugs. Servier also offers eHealth solutions beyond drug development.
In Denmark Symphogen A/S has approximately 100 people working at the Antibody Center of Excellence of Servier in several different therapeutic areas including oncology with highly efficient antibody discovery and research technologies supported by comprehensive discovery and early development capabilities. The antibody technologies deliver best or first in class potential and are well suited for combination therapies at the core of future cancer treatment.
Symphogen is a subsidiary of Servier and antibody center of excellence primarily focused on oncology and immune oncology. We have a highly efficient antibody discovery and research platform supported by comprehensive early development capabilities.
Our antibody platform delivers antibodies with unique functionalities providing best or first in class potential as combination or mono therapy. Our approach and capabilities are well suited for combination therapies at the core of future cancer treatment.
Symphogen is located in Ballerup in the greater Copenhagen area. The company currently employs approximately 150 people