Sym022 is a mAb that binds LAG3 and blocks the interaction with MHCII, thus allowing for increased T cell proliferation and cytokine production.
The Phase 1 trials are studies to test Sym021, Sym022 and Sym023 in humans in dose-escalation followed by dose-expansion studies. The primary purpose of these trials is to determine if Sym021, Sym022 and Sym023 are safe and tolerable for patients with locally advanced/unresectable or metastatic solid tumor malignancies or lymphomas that are refractory to available therapy or for which no standard therapy is available.
Clinical development of Sym022
Preclinical models have shown that combinations of Sym021, Sym022 and Sym023 provide better anti-tumor effects compared to each product candidate administered on its own. The intention is to use these product candidates in a variety of doublet or triplet combinations.
Currently, three Phase I studies are ongoing to investigate the combinations Sym021-Sym022 as well and Sym021- Sym023 and Sym021-Sym022-Sym023.
PD1, LAG3 and TIM3 are immune checkpoints playing important roles in regulating immune responses, including the body’s immune response to tumor cells.
Identifying I/O targets
Symphogen has proven its ability to deliver unique antibodies on aggressive timelines as exemplified with our filing of three INDs in six months – Sym021, Sym022 and Sym023. Such an exceptional achievement is made possible by the unique way we run projects. Developability assessment is an integrated part of
the lead selection process, which means that potential critical features of the lead candidates are taken into consideration very early in the development path.