R&D

July 28, 2012

Rozrolimupab, a mixture of 25 recombinant human monoclonal RhD antibodies, in the treatment of primary immune thrombocytopenia

Robak T, Windyga J, Trelinski J, von Depka Prondzinski M, Giagounidis A, Doyen C, Janssens A, Álvarez-Román MT, Jarque I, Loscertales J, Rus GP, Hellmann A, Jedrzejczak WW, Kuliczkowski K, Golubovic LM, Celeketic D, Cucuianu A, Gheorghita E, Lazaroiu M, Shpilberg O, Attias D, Karyagina E, Svetlana K, Vilchevska K, Cooper N, Talks K, Prabhu M, Sripada P, Bharadwaj TPR, Næsted H, Skartved NJØ, Frandsen TP, Flensburg MF, Andersen PS, Petersen J
Blood, 2012, 120, 3627-3628
November, 2011

Rational identification of an optimal antibody mixture for targeting the epidermal growth factor receptor

Koefoed K, Steinaa L, Søderberg JN, Kjær I, Jacobsen HJ, Meijer PJ, Haurum J, Jensen A, Kragh M, Andersen PS, Pedersen MW.
Landes Bioscience, 2011, 3:6, 584-595
October 15, 2011

Limits for antibody affinity maturation and repertoire diversification in hypervaccinated humans

Poulsen TR, Jensen A, Haurum JS, Andersen PS
J Immunol., 2011, 187:8, 4229-4235
September 15, 2011

Preclinical pharmacokinetics and safety of Sym004: a synergistic antibody mixture directed against epidermal growth factor receptor

Skartved NJ, Jacobsen HJ, Pedersen MW, Jensen PF, Sen JW, Hey A, Kragh M
Clin Cancer Res., 2011, 17:18, 5962-5972
September, 2011

Consistent manufacturing and quality control of a highly complex recombinant polyclonal antibody product for human therapeutic use.

Frandsen TP, Naested H, Rasmussen SK, Hauptig P, Wiberg FC, Rasmussen LK, Jensen AM, Persson P, Wikén M, Engström A, Jiang Y, Thorpe SJ, Förberg C, Tolstrup AB.
Biotechnol Bioeng., 2011, 108:9, 2171-2181
February, 2011

Capturing the natural diversity of the human antibody response against vaccinia virus.

Lantto J, Hansen MH, Rasmussen SK, Steinaa L, Poulsen TR, Duggan J, Dennis M, Naylor I, Easterbrook L, Bregenholt S, Haurum J, Jensen A.
J.Virology, 2011, 85:4, 1820-1833
August 6, 2010

Development of Mass Spectrometry Based Techniques for the Identification and Determination of Compositional Variability in Recombinant Polyclonal Antibody Products

Persson P, Rasmussen LK, Holmberg E, Frandsen TP.
Anal.Chem., 2010, 82, 7272-7282
January, 2010

Sym004: A Novel Synergistic Anti–Epidermal Growth Factor Receptor Antibody Mixture with Superior Anticancer Efficacy

Pedersen MW, Jacobsen HJ, Koefoed K, Hey A, Pyke C, Haurum JS and Kragh M
Cancer Research, 2010, 70, 588-597